Homocysteine and Cardiovascular Diseases

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Homocysteine and cardiovascular diseases.

To the Editor: Malinow et al,1 in their recent review on homocysteine and cardiovascular diseases, correctly state that based on the available evidence, it is premature to conclude that total homocysteine (tHcy) plasma levels are predictive of the development of cardiovascular events. Their conclusion is mostly based on the analysis of the results of prospective cohort studies of tHcy in cardio...

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Molecular and Biochemical Aspects of Homocysteine in Cardiovascular Diseases

Homocysteine also known as the H-factor, is a naturally occurring amino acid and is a by-product of methionine metabolism in the body. It is a common amino acid (one of the building blocks that make up proteins) found in the blood and is acquired mostly from eating meat. In 1969, a connection between homocysteine (a sulfur-containing amino acid) and cardiovascular disease was proposed when it w...

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An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism. The basis for these conclusions is data from about 80 clinical and epidemiological studies including more than 10,000 patients....

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ژورنال

عنوان ژورنال: Circulation

سال: 1999

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.100.25.e151